![]() ![]() ![]() This study was funded by the National Institutes of Health. Even small amounts of the gas can cause poisoning, and long term exposure can result in paralysis and even brain damage. People who are sleeping or drunk can die from CO poisoning before they have symptoms. If you breathe in a lot of CO it can make you pass out or kill you. CO symptoms are often described as flu-like. ![]() Bhopale, Donald Fisher, Jie Zhang, and Phyllis Gimotty. The most common symptoms of CO poisoning are headache, dizziness, weakness, upset stomach, vomiting, chest pain, and confusion. Penn colleagues on the paper are: Veena M. "Until our study elucidated this immune response, we had no motivation to think along those lines." "This opens up a lot of possibilities, such as treatment with immunosuppressant agents, in conjunction with standard hyperbaric oxygen therapy," he says. The body simply does not know when to stop attacking what it now views as an invader. If symptoms persist, and especially if the symptoms get better after you leave the building, CO may be the cause. As you continue to breathe in CO gas, your symptoms may worsen. Nausea Dizziness Weakness Confusion Disorientation Many of these symptoms are similar to the flu, food poisoning or other illnesses. Thom says that overall this work suggests that the 50 percent or more of patients who develop brain damage following severe CO poisoning may do so, in large part, due to an autoimmune reaction. The present study indicates that cognitive impairment resulting from low-level exposure to carbon monoxide may be more extensive than previously reported and. Nausea Dizziness Mild to moderate headache Tiredness or fatigue Shortness of breath. "But if you render their immune systems tolerant to altered MBP, by feeding them normal MBP before CO poisoning and thereby short-circuiting the lymphocyte response, the rats learn normally." "CO poisoned rats don't learn," said Thom. To link acute CO poisoning to long-term brain injury, the team conducted tests on normal versus CO-poisoned rats, comparing their abilities to navigate and memorize a maze. "These changes in MBP have also been demonstrated in multiple sclerosis, which is why we paralleled the study along those lines," says Thom. Specifically, the researchers found that by-products of CO metabolism in the brain alter the charge and structure of MBP. Using an animal model, they showed that the CO-induced changes in MBP set into motion an autoimmune response in which lymphocytes, triggered to eliminate altered MBP, continue to attack normal MBP. Thom, MD, PhD, Professor of Emergency Medicine and Chief of Hyperbaric Medicine, at the University of Pennsylvania School of Medicine, report this week online in the Proceedings of the National Academies of Sciences, that CO causes profound changes in myelin basic protein (MBP) – a major protein constituent of myelin, the protective sheath surrounding neurons. The physiological causes of this delayed decline were not well understood until now. Box 1 Definition of acute, chronic, and occult carbon monoxide poisoning. ![]()
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